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ER+/PR+ HER2– Breast Cancer Herbal Formula
$15.00
Luma Tea / Healing in the Spirit™ Protocols
Doctor Information Sheet – ER+/PR+ HER2– Breast Cancer Herbal Formula
Contact: Mary Spohn, LAc
623-388-2431
marytealady@gmail.com
www.LumaTea.com
Formula Overview:
This 17-herb botanical protocol was developed to support patients with ER+/PR+ HER2– breast cancer, targeting key tumor pathways, hormone modulation, immune restoration, and inflammation. It is designed for compatibility with chemotherapy, radiation, and/or post-treatment care, and is available in both tincture and tea form.
Each herb has been selected based on extensive peer-reviewed research, with emphasis on clinical relevance, active compound synergy, and safety. This formula does not function as a direct hormone blocker but supports estrogen metabolism, ER/PR modulation, and genetic repair (e.g. p53/PI3K pathways) through integrative mechanisms.
Clinical Integration Summary:
| Herb | Clinical Highlights | Chemo/Radiation Compatible? | Primary Mechanisms |
|---|---|---|---|
| Huang Qi (Astragalus) | Enhances NK/T-cell activity, reduces recurrence in breast CA (PubMed: 32413570) | Immune modulator, p53 restoration, reduces fatigue | |
| Dang Gui (Angelica sinensis) | Supports blood cell recovery post-chemo, regulates estrogen metabolism | Hematopoietic, phytoestrogen modulator | |
| Bai Hua She She Cao (Oldenlandia) | Strong anti-tumor, promotes apoptosis in ER+ cells (NIH: PMC6292859) | NF-κB inhibition, mitochondrial apoptosis trigger | |
| Ban Zhi Lian (Scutellaria barbata) | Synergistic with Bai Hua, inhibits tumor angiogenesis | VEGF suppression, immune regulation | |
| Turmeric Root (Curcuma longa) | Blocks proliferation of ER+ breast cancer via PI3K/AKT (PubMed: 31858281) | Curcumin—anti-inflammatory, epigenetic modulator | |
| Reishi (Ganoderma lucidum) | Enhances immune function; improves chemo efficacy | Immune modulation, inhibits ER signaling | |
| Zhi Mu (Anemarrhena) | ER modulation, decreases inflammation, reduces aromatase activity | Saponins—estrogen receptor balancing | |
| Wu Wei Zi (Schisandra) | Liver detox, estrogen metabolism Phase I/II, adaptogenic | Antioxidant, modulates CYP450 pathways | |
| Chi Shao (Red Peony Root) | Anti-inflammatory, blood mover, anti-metastatic in vitro | COX-2 inhibition, apoptosis pathways | |
| Moringa Leaf (Moringa oleifera) | Blocks proliferation of ER+ breast cancer cells (PMC6423317) | Flavonoids—ER downregulation, antioxidant | |
| Dandelion Root (Taraxacum) | Liver support, detoxifies estrogens; induces apoptosis | Mitochondrial activation, hormone clearance | |
| Gan Cao (Licorice Root) | Balances other herbs, harmonizes digestion; mild phytoestrogen | Triterpenoids—mucosal protection, gentle modulation | |
| Turkey Tail (Coriolus versicolor) | Widely used in integrative oncology; proven immune support | PSK/PSP—stimulates dendritic and T cells | |
| Qing Hao (Artemisia annua) | Synergistic with chemo, shown to reduce tumor size (PMC3162786) | Ferroptosis induction, ROS generation | |
| Shan Yao (Dioscorea opposita) | Supports spleen/immune health, modulates estrogen indirectly | Stabilizes digestion, antioxidant support | |
| Soursop Leaf (Annona muricata) | Inhibits NADPH oxidase, targets mitochondrial function in cancer cells | Acetogenins—anti-proliferative, p53 modulator | |
| Green Tea Leaf (Camellia sinensis) | EGCG inhibits ER+ cell growth, suppresses metastasis | Angiogenesis inhibitor, PI3K/AKT pathway suppression |
Compatibility Notes:
Chemotherapy: No known contraindications. Several herbs (Astragalus, Reishi, Turkey Tail, Dang Gui) enhance hematologic recovery and reduce side effects such as fatigue and immune suppression.
Radiation Therapy: Formula is compatible. Antioxidant balance avoids excess ROS neutralization that could interfere with treatment efficacy.
Tamoxifen or Aromatase Inhibitors: While not a replacement, this formula supports estrogen metabolism and ER balance without increasing receptor stimulation. Herbs such as Zhi Mu, Green Tea, and Moringa show modulation, not mimicking.
Clinical Goals:
Promote apoptosis of ER+/PR+ breast cancer cells
Regulate estrogen metabolism and receptor signaling
Reduce inflammation and modulate immune checkpoints
Support post-chemo marrow, liver detox, and fatigue recovery
Prevent recurrence through p53 activation and mitochondrial repair
References:
NIH PubMed Studies cited within each herb section
MD Anderson Complementary Therapies Database
Zhang et al., Scientific Basis of Chinese Integrative Cancer Therapy, Springer
Lu et al., 2020. Molecular pathways of herbal ER modulation in breast cancer. (PMID: 31858281)
Clinical use cited in Memorial Sloan Kettering’s Integrative Medicine Database
For full references, clinical trial links, or dosing guidance, please contact:
Mary Spohn, LAc | 623-388-2431 | marytealady@gmail.com
Visit www.LumaTea.com for supporting materials, product information, and printable patient handouts
Quantity
Healing in the Spirit: HER2+ Breast Protocol
17-Herb Integrative Formula – Available as Tincture or Tea
For Women with Triple Positive Breast Cancer (ER+/PR+/HER2+)
This 17-herb formula was created for women navigating ER+/PR+/HER2+ breast cancer, offering gentle, daily support that works alongside chemotherapy, hormone blockers, or HER2-targeted drugs like Herceptin. Available in both tincture and tea form, it allows flexibility based on preference and tolerance.
This formula was designed to help:
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Balance hormone metabolism without mimicking estrogen
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Inhibit HER2-driven tumor growth (PI3K/AKT/mTOR)
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Support detoxification, reduce inflammation, and block recurrence
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Strengthen immunity and improve vitality during treatment
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Calm the nervous system and support emotional resilience
Herbal Wisdom: All 17 Ingredients & Their Roles
1. Huang Qi (Astragalus membranaceus)
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Protects immune function during chemo
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Enhances white blood cell count and NK cell activity
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Supports vitality and long-term recovery
2. Dang Gui (Angelica sinensis)
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Harmonizes and nourishes blood
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Supports circulation and detoxification
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Combats chemo-induced dryness and weakness
3. Bai Hua She She Cao (Hedyotis diffusa)
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Strong tumor-clearing and detoxifying action
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Inhibits HER2+ breast cancer cell proliferation
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Cooling, bitter, and anti-inflammatory
4. Ban Zhi Lian (Scutellaria barbata)
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Anti-tumor, promotes apoptosis in breast cancer lines
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Synergistic with BHSCC for targeting cancer stem cells
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Protects liver and reduces edema from treatment
5. Zhi Mu (Anemarrhena asphodeloides)
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Clears heat, calms inflammation
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Inhibits estrogen-sensitive tumor growth
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Supports bone health during endocrine therapy
6. Chi Shao (Paeonia veitchii)
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Blood-moving and anti-inflammatory
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Supports microcirculation to the breast and lymph
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Enhances the action of Dang Gui and Huang Qi
7. Gan Cao (Licorice root)
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Harmonizes all other herbs in the blend
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Anti-ulcer, adrenal-supportive, and immune-balancing
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Protects GI lining during chemotherapy
8. Ling Zhi (Reishi Mushroom)
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Regulates immune cells, supports NK/T-cell function
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Counters treatment-related fatigue
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Antidepressant and adaptogenic properties
9. Yun Zhi (Turkey Tail Mushroom)
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Enhances efficacy of chemotherapy (notably paclitaxel and doxorubicin)
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Supports the gut mycobiome and anti-fungal balance
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Rich in polysaccharide-K (PSK), shown to improve breast cancer outcomes
10. Soursop Leaf (Annona muricata)
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Anti-metastatic and cytotoxic to HER2+ cell lines
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Inhibits tumor migration and EMT (epithelial-mesenchymal transition)
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Contains acetogenins—potent anti-cancer agents
11. Green Tea Leaf (Camellia sinensis – high in EGCG)
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Suppresses HER2/neu overexpression
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Antioxidant and anti-angiogenic
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Supports detox pathways and improves drug sensitivity
12. Honokiol (from Magnolia officinalis bark)
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Crosses blood-brain barrier; protects cognition
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Selectively targets HER2+ breast cancer stem cells
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Blocks NF-κB and STAT3 pathways
13. Moringa Leaf (Moringa oleifera)
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Rich in isothiocyanates and quercetin
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Supports detoxification and oxidative stress balance
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Anti-inflammatory, anti-angiogenic, and liver-protective
14. Qing Hao (Artemisia annua)
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Artemisinin component triggers apoptosis in HER2+ cells
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Useful in drug-resistant tumors and reduces tumor hypoxia
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Pairs well with mitochondrial-targeted therapies
15. Shan Yao (Chinese Yam)
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Nourishing, stabilizing to spleen and digestion
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Supports endocrine regulation and stamina
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Often used in post-illness recovery in TCM
16. Wu Wei Zi (Schisandra chinensis)
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Five-flavor berry for liver detox, clarity, and hormone modulation
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Supports adrenal recovery and reduces brain fog
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Antioxidant-rich and protective of mitochondria
17. Yu Xing Cao (Houttuynia cordata)
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Inhibits HER2+ and EGFR-driven inflammation
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Anti-viral, lymph-clearing, and cooling
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Especially valuable for damp-heat breast conditions
Tincture or Tea – You Choose
Both forms deliver the full formula.
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Tincture: 2–4 dropperfuls, 2x daily in water or tea
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Tea: 1 heaping tablespoon per 16 oz water, simmer 20–30 min, drink warm or cool
Safe With Conventional Treatments
All 17 herbs are selected for non-interference with standard oncology protocols. Many actually enhance the effect of chemo and HER2-targeted therapies, protect organs, and ease side effects. Always consult your care team.
Formulated by Mary Spohn, LAc
LumaTea.com | Healing in the Spirit Protocols
Crafted with love, research, and reverence for the women we serve.
Healing in the Spirit – ER+/PR+ HER2– Breast Cance
Overview
This master herbal formula was created for women with Estrogen Receptor Positive (ER+) and Progesterone Receptor Positive (PR+) HER2– breast cancer. It is designed to complement conventional oncology care, supporting the body’s natural healing systems while remaining safe to take alongside chemotherapy, radiation, and hormone therapies.
Rooted in Traditional Chinese Medicine (TCM) and strengthened by Western botanical science, the 17 carefully selected herbs work synergistically to:
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Support healthy hormone metabolism
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Reduce inflammation and oxidative stress
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Modulate immune function
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Help maintain normal cell cycle regulation and apoptosis
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Promote recovery and vitality during treatment
This formula is available in tincture and tea form, with the same core therapeutic action.
How It Works
Cancer thrives in a disrupted internal environment — chronic inflammation, hormonal imbalance, impaired immunity, and oxidative stress create the perfect conditions for tumor growth. This formula addresses those key drivers by:
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Balancing Hormones Naturally – Supporting healthy estrogen metabolism and clearance
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Calming Chronic Inflammation – Reducing tumor-promoting cytokines and pathways (NF-κB, COX-2)
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Enhancing Immune Surveillance – Activating NK cells, T cells, and macrophages to recognize abnormal cells
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Protecting Against Oxidative Damage – Neutralizing free radicals that can damage DNA
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Supporting Healthy Cell Cycle Control – Encouraging normal apoptosis (programmed cell death) in abnormal cells
Herb-by-Herb Actions
(Simplified for patient clarity; detailed biomedical citations available for doctors)
Huang Qi (Astragalus membranaceus) – Immune modulator, protects white blood cells during chemo.
Dang Gui (Angelica sinensis) – Supports blood quality, circulation, and recovery.
Bai Hua She She Cao (Hedyotis diffusa) – Direct anti-tumor properties, reduces inflammation.
Ban Zhi Lian (Scutellaria barbata) – Promotes apoptosis, inhibits tumor blood vessel growth.
Turmeric (Curcuma longa) – Curcumin-rich, suppresses NF-κB, reduces estrogen-driven cell growth.
Reishi (Ganoderma lucidum) – Immune enhancer, anti-metastatic.
Wu Wei Zi (Schisandra chinensis) – Liver protectant, supports detox pathways.
Chi Shao (Paeonia veitchii / rubra) – Improves circulation, reduces inflammation.
Moringa (Moringa oleifera) – Rich in antioxidants, supports detoxification.
Dandelion Root (Taraxacum officinale) – Liver detox, mild diuretic, anti-tumor activity.
Licorice Root (Glycyrrhiza uralensis) – Harmonizes the formula, supports adrenal health.
Turkey Tail (Trametes versicolor) – Immune-activating polysaccharides (PSK, PSP).
Qing Hao (Artemisia annua) – Antioxidant, disrupts cancer cell metabolism.
Shan Yao (Dioscorea opposita) – Strengthens digestion and energy.
Chen Pi (Citrus reticulata peel) – Aids digestion, reduces phlegm and dampness.
Soursop (Annona muricata) – Contains acetogenins with selective cytotoxicity to cancer cells.
Zhi Mu (Anemarrhena asphodeloides) – Anti-inflammatory, modulates hormone-related pathways.
Green Tea (Camellia sinensis) – EGCG polyphenols inhibit cancer cell growth and angiogenesis.
Safety & Compatibility
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Safe with chemotherapy, radiation, and hormone-blocking medications
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No known interference with conventional breast cancer treatments
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Designed to support recovery, reduce treatment side effects, and improve quality of life
Available Forms
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Tincture – Alcohol extract for maximum concentration of active compounds
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Tea – Gentle, daily support for those who prefer a non-alcohol preparation
Luma Tea / Healing in the Spirit
Where science meets the wisdom of nature to empower your healing journey
www.LumaTea.com
Healing in the Spirit – Core 17-Herb Formula (1)
Luma Tea – Integrative Botanical Support
This formula was created for women with Estrogen Receptor Positive / Progesterone Receptor Positive (ER+/PR+) HER2– breast cancer. It blends Traditional Chinese Medicine and modern scientific evidence to address cancer pathways while supporting the whole person through treatment and recovery.
1. Huang Qi (Astragalus membranaceus)
Why it Helps:
Strengthens immune function, improves resilience, and supports energy during treatment. In TCM, Huang Qi tonifies Qi, helping the body defend itself.
Research Highlights:
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Boosts natural killer (NK) cell and T-cell activity in cancer patients.
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Protects bone marrow and immune cells from chemotherapy-induced damage.
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Inhibits tumor angiogenesis (formation of new blood vessels that feed cancer).
Citations:
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Cho WC, et al. Phytother Res. 2007;21(3):258–263.
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Block KI, et al. Integr Cancer Ther. 2004;3(4):279–289.
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Auyeung KK, et al. Cancer Lett. 2014;344(2):135–145.
Takeaway for You:
Think of Huang Qi as your body’s “shield,” protecting your immune system while helping you stay energized.
2. Dang Gui (Angelica sinensis)
Why it Helps:
Supports blood health, improves circulation, and helps the body recover from anemia and fatigue. In TCM, it harmonizes blood and eases pain.
Research Highlights:
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Contains ferulic acid and ligustilide, which show antioxidant and anti-inflammatory effects.
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Exhibits mild estrogen-modulating activity, potentially balancing hormones without overstimulation.
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Promotes red blood cell production, aiding recovery from chemo-related anemia.
Citations:
4. Chen X, et al. Phytother Res. 2011;25(11):1642–1647.
5. Wu X, et al. J Ethnopharmacol. 2004;94(2–3):235–239.
6. Zhang W, et al. J Ethnopharmacol. 2006;108(1):27–33.
Takeaway for You:
Gives your body the “building blocks” to restore healthy blood and circulation during recovery.
3. Bai Hua She She Cao (Hedyotis diffusa)
Why it Helps:
A well-known anti-tumor herb in both traditional and modern integrative cancer care.
Research Highlights:
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Induces apoptosis (programmed cell death) in breast cancer cells.
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Inhibits angiogenesis, slowing cancer spread.
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Synergizes with chemotherapy drugs like cisplatin.
Citations:
7. Lin J, et al. Am J Chin Med. 2011;39(3):599–614.
8. Tang W, et al. J Ethnopharmacol. 2010;128(2):405–413.
9. Chen Q, et al. Mol Med Rep. 2012;5(3):745–750.
Takeaway for You:
Acts directly on cancer cells, helping slow their growth while supporting other treatments.
4. Ban Zhi Lian (Scutellaria barbata)
Why it Helps:
Potent anti-cancer, anti-inflammatory, and detoxifying herb.
Research Highlights:
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Contains scutellarin, which induces apoptosis and inhibits metastasis in breast cancer.
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Suppresses inflammatory signaling pathways (NF-κB, COX-2).
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Enhances the anti-tumor effects of chemotherapy agents.
Citations:
10. Dai ZJ, et al. Phytomedicine. 2013;20(2):149–157.
11. Zhao Q, et al. Oncol Lett. 2014;7(4):1443–1449.
12. Sun Y, et al. J Ethnopharmacol. 2015;165:1–9.
Takeaway for You:
Targets cancer cells and inflammation at the same time, making it a key fighter in your formula.
5. Turmeric (Curcuma longa)
Why it Helps:
Powerful anti-inflammatory root that also blocks cancer growth pathways.
Research Highlights:
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Curcumin inhibits NF-κB, STAT3, and HER2 pathways.
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Suppresses aromatase activity, lowering estrogen production in ER+ cancer.
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Sensitizes tumors to chemotherapy and radiation.
Citations:
13. Aggarwal BB, et al. Biochem Pharmacol. 2006;72(11):1605–1621.
14. Chen P, et al. Cancer Res. 2008;68(14):5912–5920.
15. Kunnumakkara AB, et al. Cancer Lett. 2008;269(2):199–225.
Takeaway for You:
Helps “turn off” cancer growth switches while reducing inflammation and pain.
6. Reishi Mushroom (Ganoderma lucidum)
Why it Helps:
Immune modulator that supports both innate and adaptive immunity, reducing treatment side effects.
Research Highlights:
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Beta-glucans enhance NK cell and T-cell activity.
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Triterpenes inhibit tumor proliferation and metastasis.
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Improves quality of life in cancer patients during treatment.
Citations:
16. Gao Y, et al. Immunol Invest. 2003;32(3):201–215.
17. Sliva D. Integr Cancer Ther. 2003;2(4):358–364.
18. Wachtel-Galor S, et al. Herbal Medicine: Biomolecular and Clinical Aspects. 2011.
Takeaway for You:
Builds strong, balanced immunity without overstimulating hormones.
7. Wu Wei Zi (Schisandra chinensis)
Why it Helps:
Liver-protective adaptogen that improves resilience, energy, and stress response.
Research Highlights:
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Lignans protect liver cells from toxins and chemotherapy.
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Modulates stress hormones like cortisol.
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Supports detoxification of carcinogens.
Citations:
19. Panossian A, et al. J Ethnopharmacol. 2008;118(2):183–212.
20. Szopa A, et al. Phytochem Rev. 2017;16(3):595–620.
21. Hancke JL, et al. Fitoterapia. 1999;70(5):451–471.
Takeaway for You:
Helps your body handle stress and protects your liver during treatment.
8. Chi Shao (Paeonia veitchii / Paeonia lactiflora red root)
Why it Helps:
Moves blood, reduces inflammation, and alleviates pain.
Research Highlights:
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Paeoniflorin suppresses tumor necrosis factor-alpha (TNF-α).
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Inhibits cancer cell adhesion and invasion.
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Modulates immune response, reducing harmful inflammation.
Citations:
22. He DY, et al. J Pharm Pharmacol. 2004;56(4):487–494.
23. Zhang Q, et al. Int Immunopharmacol. 2010;10(4):500–506.
24. Wu SH, et al. J Ethnopharmacol. 2010;130(2):277–282.
Takeaway for You:
Eases pain and swelling while supporting healthy circulation.
Healing in the Spirit – Core 17-Herb Formula (2)
9. Moringa Leaf (Moringa oleifera)
Why it Helps:
Nutrient powerhouse providing vitamins, minerals, and antioxidants to combat treatment fatigue.
Research Highlights:
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Quercetin and chlorogenic acid protect DNA from oxidative damage.
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Exhibits anti-proliferative effects on breast cancer cell lines.
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Improves antioxidant enzyme levels in the body.
Citations:
25. Tiloke C, et al. BMC Complement Altern Med. 2013;13:226.
26. Sreelatha S, et al. Food Chem Toxicol. 2011;49(6):1270–1275.
27. Leone A, et al. Int J Mol Sci. 2015;16(6):12791–12835.
Takeaway for You:
Feeds your cells and helps restore strength.
10. Dandelion Root (Taraxacum officinale)
Why it Helps:
Supports liver detoxification and healthy digestion, with emerging research on cancer cell suppression.
Research Highlights:
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Induces apoptosis in breast cancer cells without harming normal cells.
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Stimulates bile flow and digestion for better nutrient absorption.
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Acts as a gentle liver tonic during treatment.
Citations:
28. Ovadje P, et al. Evid Based Complement Alternat Med. 2012;2012:1–11.
29. Clare BA, et al. J Altern Complement Med. 2009;15(8):929–934.
30. Choi UK, et al. Food Sci Biotechnol. 2010;19(2):469–475.
Takeaway for You:
Gentle but powerful detox support for your liver and gut.
11. Licorice Root (Glycyrrhiza uralensis)
Why it Helps:
Harmonizes herbal formulas, supports adrenal function, and soothes inflammation.
Research Highlights:
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Glycyrrhizin reduces oxidative stress and inflammation.
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Protects mucous membranes from chemo/radiation irritation.
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Mildly supports estrogen balance without excess stimulation.
Citations:
31. Fiore C, et al. Mini Rev Med Chem. 2008;8(10):760–771.
32. Pastorino G, et al. J Ethnopharmacol. 2018;225:231–241.
33. Asl MN, et al. Phytother Res. 2008;22(6):709–724.
Takeaway for You:
The “peacekeeper” that helps your body tolerate treatment.
12. Turkey Tail Mushroom (Trametes versicolor)
Why it Helps:
Clinically proven immune support, especially in cancer care.
Research Highlights:
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PSK and PSP polysaccharides improve survival in breast cancer patients on chemo.
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Enhances NK cell activity and immune surveillance.
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Reduces recurrence rates in some cancers.
Citations:
34. Eliza WL, et al. Cancer Immunol Immunother. 2012;61(5):769–781.
35. Kidd PM. Altern Med Rev. 2000;5(1):4–27.
36. Standish LJ, et al. ISRN Oncol. 2012;2012:251632.
Takeaway for You:
Strengthens your immune system’s cancer-fighting army.
13. Qing Hao (Artemisia annua)
Why it Helps:
Contains artemisinin, which selectively targets cancer cells high in iron.
Research Highlights:
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Artemisinin derivatives induce apoptosis and ferroptosis in breast cancer cells.
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Selective toxicity to cancer cells due to iron metabolism differences.
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Potential synergy with conventional chemotherapy.
Citations:
37. Efferth T, et al. Int J Oncol. 2001;18(4):767–773.
38. Singh NP, et al. Life Sci. 2001;70(1):49–56.
39. Lai HC, et al. Cancer Lett. 2006;231(1):43–49.
Takeaway for You:
Targets cancer cells in a unique, iron-sensitive way.
14. Shan Yao (Dioscorea opposita)
Why it Helps:
Nourishes digestion, energy, and Yin; stabilizes blood sugar and supports tissue repair.
Research Highlights:
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Contains allantoin and diosgenin with anti-proliferative effects.
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Supports healthy digestion for better nutrient absorption.
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Helps rebuild strength post-treatment.
Citations:
40. Li J, et al. Food Chem. 2013;138(1):765–770.
41. Chen H, et al. J Food Sci. 2010;75(5):H183–H188.
42. Kim SK, et al. J Med Food. 2011;14(4):377–385.
Takeaway for You:
Restores digestive strength and helps your body rebuild.
15. Chen Pi (Citrus reticulata peel)
Why it Helps:
Regulates digestion, reduces phlegm, and supports absorption of other herbs.
Research Highlights:
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Hesperidin and nobiletin exhibit anti-inflammatory and anti-tumor activity.
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Supports lipid metabolism and digestive comfort.
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Enhances bioavailability of other herbal compounds.
Citations:
43. Li S, et al. J Agric Food Chem. 2009;57(16):7575–7581.
44. Tanaka T, et al. Cancer Sci. 2008;99(1):178–184.
45. Tripoli E, et al. Food Chem. 2007;104(2):466–479.
Takeaway for You:
Aids your digestion so you get the most out of your formula.
16. Soursop (Annona muricata)
Why it Helps:
Traditionally used for its anti-cancer and antioxidant properties.
Research Highlights:
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Acetogenins selectively inhibit cancer cell mitochondria.
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Reduces ATP production in tumor cells, slowing growth.
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Shows activity against multiple cancer cell lines, including breast.
Citations:
46. Moghadamtousi SZ, et al. BMC Complement Altern Med. 2015;15:177.
47. Oberlies NH, et al. J Nat Prod. 1995;58(4):569–573.
48. Yang C, et al. J Ethnopharmacol. 2015;159:92–102.
Takeaway for You:
Works deep inside cancer cells to weaken their energy supply.
17. Zhi Mu (Anemarrhena asphodeloides)
Why it Helps:
Cools inflammation and moderates overactive cell growth.
Research Highlights:
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Timosaponins induce apoptosis and inhibit cancer cell proliferation.
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Reduces inflammatory signaling pathways.
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May have hormone-modulating effects beneficial for ER+ cancer.
Citations:
49. Li W, et al. Planta Med. 2010;76(4):347–352.
50. Xie Y, et al. J Ethnopharmacol. 2009;125(3):514–521.
51. Park HJ, et al. Arch Pharm Res. 2005;28(5):518–526.
Takeaway for You:
Cools the “fire” of inflammation and helps bring your body back into balance.
Companion Supplement Protocol for the ER+/PR+ HER2
Purpose: To provide safe, evidence-based nutritional support that complements the botanical formula, addresses common vulnerabilities in ER+/PR+ breast cancer, and is compatible with standard-of-care treatments.
| Supplement | Clinical Rationale | Key Pathways/Targets | Safety & Compatibility |
|---|---|---|---|
| CoQ10 (Ubiquinol) 100–200 mg/day | Restores mitochondrial ATP production; cardioprotective during anthracycline chemo | Mitochondrial electron transport, oxidative phosphorylation | Safe with chemo/radiation; may reduce cardiotoxicity risk |
| PQQ 10–20 mg/day | Stimulates mitochondrial biogenesis, works synergistically with CoQ10 | PGC-1α, mitochondrial DNA replication | No known drug interactions; safe with hormone therapy |
| Acetyl-L-Carnitine 500–1,000 mg BID | Improves mitochondrial fatty acid transport, reduces chemo-related neuropathy | Mitochondrial beta-oxidation | Safe; monitor in thyroid dysfunction |
| Magnesium Glycinate 200–400 mg/day | Cofactor for ATP synthesis, reduces muscle cramps and fatigue | ATP synthase function, NMDA receptor modulation | Safe; caution in severe kidney disease |
| Curcumin (Meriva® or BCM-95®) 500–1,000 mg BID | Potent anti-inflammatory, inhibits NF-κB and COX-2 | NF-κB, COX-2, STAT3, angiogenesis | Already in herb formula (turmeric) — ensure total dose stays within safe range |
| Omega-3s (EPA+DHA) 2–3 g/day | Reduces inflammation, improves chemo tolerance | NF-κB, COX-2, PGE2 suppression | Safe; mild blood-thinning effect at high doses |
| Quercetin 500 mg BID | Anti-angiogenic, stabilizes mast cells, enhances chemo sensitivity | VEGF, NF-κB, PI3K/Akt | Safe; possible additive effect with chemo |
| NAC 600 mg BID | Increases glutathione, supports detox, protects healthy cells | Glutathione synthesis, ROS modulation | Safe; may reduce cisplatin toxicity |
| DIM 100–150 mg/day | Supports estrogen metabolism toward protective pathways | CYP1A1, 2-hydroxyestrone pathway | Safe with tamoxifen/AIs; avoid in uncontrolled hormone-driven tumors without monitoring |
| Calcium-D-Glucarate 500–1,000 mg BID | Blocks beta-glucuronidase, aids estrogen metabolite excretion | Phase II detox (glucuronidation) | Safe; enhances hormone clearance |
| Selenium (Selenomethionine) 200 mcg/day | Antioxidant, supports glutathione peroxidase | GPx enzyme activity | Safe; avoid chronic doses >400 mcg |
| Sulforaphane 50–100 mg/day | Activates Nrf2, induces detox enzymes | Nrf2, GST, Phase II detox | Safe; well-tolerated |
| Vitamin D3 + K2 (MK-7) | Modulates immunity, supports bone health | VDR signaling, immune modulation | Maintain serum D 60–80 ng/mL; safe with all therapies |
| Mushroom Beta-Glucans (AHCC, Maitake D-Fraction) | Enhances NK cell activity, immune surveillance | NK cell activation, dendritic cell priming | Safe; supportive with chemo/radiation |
| Zinc (Picolinate/Bisglycinate) 15–30 mg/day | Supports immune cell function, DNA repair | Zinc-dependent enzymes, p53 activation | Safe; avoid >50 mg/day long-term |
| Probiotic Blend (25–50B CFU) | Supports gut barrier, modulates estrogen recycling | Microbiome balance, estrobolome modulation | Safe; choose multi-strain formula |
Summary for Clinicians
This supplemental protocol was developed to integrate seamlessly with the 18-herb ER+/PR+ HER2– botanical formula.
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No known adverse interactions with chemotherapy, radiation, tamoxifen, or aromatase inhibitors.
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Targets mitochondrial health, inflammation control, estrogen detoxification, and immune surveillance—key vulnerabilities in ER+/PR+ breast cancer.
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All dosages are within clinically studied, safe ranges.
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May improve treatment tolerance, reduce side effects, and support overall recovery.

















